Fluid Overload-Associated Large B-Cell Lymphoma: A Case Report and Review of Literature

Fluid overload-associated large B-cell lymphoma (FO-LBCL) is a new entity described in the fifth edition of World Health Organization (WHO) Classification Hematolymphoid Tumors (WHO-HAEM5). It refers to malignant present with symptoms serous effusions body cavities (pleural, peritoneal, and/or pericardial) absence an identifiable tumor mass. We case 82-year-old man history atrial fibrillation and flutter, status post-ablation, essential hypertension (HTN), hyperlipidemia (HLD), diabetes mellitus (DM) type 2 who was referred our hospital for shortness breath due recurrent pleural effusion. Right video-assisted thoracoscopy right biopsy performed. Histopathological examination revealed dense fibrous tissue, chronic inflammation, lymphoid aggregates, granulation no evidence lymphoma. Cytology fluid cells, which were positive CD45, CD20, PAX-5, MUM-1, BCL2, BCL6, MYC protein. They negative CD3, CD10, CD138, HHV-8 by immunohistochemistry (IHC). Epstein–Barr virus (EBV) situ hybridization (ISH). Due any elsewhere, diagnosis made. provide synopsis main clinicopathological features FO-LBCL two differential diagnoses, primary effusion (PEL) diffuse (DLBCL).